This mixed media folk piece depicts a photograph of the 1648 Sayre House framed within a wooden recreation of the Sayre House's architectural design. The angles and depth of both sides of the shingled roof are the most notable features of this piece, as well as the large "window" which houses the photo of the home. A smaller window is seen just above the photo, albeit with a shard missing from the glass (perhaps intentionally). It's rumored that parts of the Sayre House's original wooden structure was used in the construction of this piece, but nothing is confirmed as of yet.
This particular photo of the Sayre House has been printed numerous times on a variety of postcards during the early 20th century, in a variety of black and white shades as well as colorized reproductions.